Here, the authors show that chronic blockade of neuronal activity reduces the connectivity of recurrent CA3-CA3 neurons in the rodent hippocampus while the synaptic strength of the remaining recurrent connections increased approximately twofold. They also show that this homeostatic process is mediated by the changes in presynaptic release probability regulated by cyclin-dependent kinase 5.
- Ananya Mitra
- Siddhartha S Mitra
- Richard W Tsien
