The role of the tRNAome in virus-host interaction is poorly understood. Here, the authors report a dual role of the host tRNAome showing that it is remodeled by IFN-α to regulate antiviral defenses, yet can be exploited by hepatitis viruses to benefit infection, particularly when host antiviral responses are not induced.
- Xumin Ou
- Xiaoming Lin
- Anchun Cheng
