The authors demonstrate that mechanical strain enhances proliferation and migration of breast cancer (BCa) cells. Oscillatory strain (OS)-exposed triple negative breast cancer cells produced more exosomes with immunomodulatory potential. Preconditioning BCa cells with OS before transplantation in vivo increased tumor growth, infiltration of immunesuppressive myeloid-lineage cells, and enhanced exosome-mediated cellular cross-talk.
- Yong Wang
- Kayla F. Goliwas
- Jessy S. Deshane
