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Showing 1–2 of 2 results
Advanced filters: Author: Andre Horatscheck Clear advanced filters

  • Here, Reader et al. screen the Medicines for Malaria Venture Pandemic Response Box in parallel against Plasmodiumasexual and liver stage parasites, stage IV/V gametocytes, gametes, oocysts and as endectocides. They identify two potent transmission-blocking drugs: a histone demethylase inhibitor ML324 and the antitubercular SQ109.

    • Janette Reader
    • Mariëtte E. van der Watt
    • Lyn-Marié Birkholtz
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-15

  • Compound library screening combined with medicinal chemistry and structural biology approaches enables the development of potent and highly selective cell-permeable small-molecule inhibitors of phosphatidylinositol 3-kinase C2α activity and function.

    • Wen-Ting Lo
    • Hassane Belabed
    • Volker Haucke
    ResearchOpen Access
    Nature Chemical Biology
    Volume: 19, P: 18-27