Nature Search

The aging mouse CNS is protected by an autophagy-dependent microglia population promoted by IL-34

Microglia could have health-promoting capacities in age-associated neuroinflammation. Here, the authors describe an autophagy and IL-34 dependent neuroprotective microglia population in the aging brain as a potential therapeutic target.

Rasmus Berglund
Yufei Cheng
Maja Jagodic
ResearchOpen Access09 Jan 2024
Nature Communications

Volume: 15, P: 1-19
A pan-cancer signature for dysfunctional T cells

A preprint by Jerby-Arnon et al. uses a novel algorithm for scRNAseq data to describe a pan-cancer programme for dysfunctional tumour-infiltrating lymphocytes that predicts response to immune checkpoint blockade therapy.

Nicolas Ruffin
Andre Ortlieb Guerreiro-Cacais
Research Highlights15 Dec 2021
Nature Reviews Immunology

Volume: 22, P: 74
Distinct transcriptomic and epigenomic responses of mature oligodendrocytes during disease progression in a mouse model of multiple sclerosis

Single-cell ATAC/RNA multiomic profiling was used to investigate how oligodendrocyte lineage cells respond across multiple disease stages within a mouse MS model, revealing early activation of immune genes along with oligodendrocyte subtype-specific responses.

Chao Zheng
Bastien Hervé
Gonçalo Castelo-Branco
ResearchOpen Access17 Nov 2025
Nature Neuroscience

Volume: 28, P: 2612-2627
Fatal demyelinating disease is induced by monocyte-derived macrophages in the absence of TGF-β signaling

Harris and colleagues show that the cytokine TGF-β is required for colonization of the microglial niche and maintenance of central nervous system integrity. Acute loss of TGF-β leads to proinflammatory responses and fatal demyelinating disease.

Harald Lund
Melanie Pieber
Robert A. Harris
Research16 Apr 2018
Nature Immunology

Volume: 19, P: 1-7
Disease-specific oligodendrocyte lineage cells arise in multiple sclerosis

Single-cell RNA-seq of a mouse model of multiple sclerosis uncovers new oligodendrocyte populations and putative disease markers and suggests new mechanisms underlying the pathogenesis of the disease.

Ana Mendanha Falcão
David van Bruggen
Gonçalo Castelo-Branco
Research12 Nov 2018
Nature Medicine

Volume: 24, P: 1837-1844
Combined sequence-based and genetic mapping analysis of complex traits in outbred rats

The Rat Genome Sequencing and Mapping Consortium reports a combined sequence-based and genetic mapping analysis of 160 phenotypes in an outbred rat heterogeneous stock. They identify 31 genes involved in 27 different phenotypes.

Amelie Baud
Roel Hermsen
Jonathan Flint
Research26 May 2013
Nature Genetics

Volume: 45, P: 767-775
Erratum: Genomes and phenomes of a population of outbred rats and its progenitors

Amelie Baud
Victor Guryev
Jonathan Flint
Amendments and Corrections08 Jul 2014
Scientific Data

Volume: 1, P: 1
VAV1 regulates experimental autoimmune arthritis and is associated with anti-CCP negative rheumatoid arthritis

A O Guerreiro-Cacais
U Norin
L Padyukov
Research05 Jan 2017
Genes & Immunity

Volume: 18, P: 48-56
Genomes and phenomes of a population of outbred rats and its progenitors

Amelie Baud
Victor Guryev
Jonathan Flint
ResearchOpen Access10 Jun 2014
Scientific Data

Volume: 1, P: 1-15

Search

Filter By:

Search

Quick links