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Showing 1–5 of 5 results
Advanced filters: Author: Andrea B. Alber Clear advanced filters
  • The 4D Nucleome Project demonstrates the use of genomic assays and computational methods to measure genome folding and then predict genomic structure from DNA sequence, facilitating the discovery of potential effects of genetic variants, including variants associated with disease, on genome structure and function.

    • Job Dekker
    • Betul Akgol Oksuz
    • Feng Yue
    ResearchOpen Access
    Nature
    Volume: 649, P: 759-776
  • Mammalian transcription factors (TFs) differ broadly in their DNA binding properties. Here authors quantify mitotic chromosome binding (MCB) of 501 TFs and suggest that MCB can be used as a proxy for non-specific TF-DNA interactions that regulate TF search for specific genomic sites.

    • Mahé Raccaud
    • Elias T. Friman
    • David M. Suter
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-16
  • Mesenchymal lineages play critical roles during development, though these cells are frequently overlooked in directed differentiation models. Here they derive lung-specific mesenchyme from mouse iPSCs and generate organoids consisting of both mesenchymal and epithelial progenitors, observing functional epithelial-mesenchymal crosstalk.

    • Andrea B. Alber
    • Hector A. Marquez
    • Darrell N. Kotton
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-18
  • Many job sectors classified as ‘essential’ have continued operating with limited restrictions during the COVID-19 pandemic, potentially placing workers at higher risk of infection. Here, the authors show that seropositivity rates in workers vary widely across and between job sectors in Geneva, Switzerland.

    • Silvia Stringhini
    • María-Eugenia Zaballa
    • Idris Guessous
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-7