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Interaction of the cotranslational Hsp70 Ssb with ribosomal proteins and rRNA depends on its lid domain

In yeast, the heterodimeric ribosome-associated complex (RAC) acts in concert with the Hsp70 protein Ssb, forming a unique chaperone triad. Here the authors use structural and biochemical approaches to shed light on how translation and folding are coupled in eukaryotes.

Andrea Gumiero
Charlotte Conz
Irmgard Sinning
ResearchOpen Access24 Nov 2016
Nature Communications

Volume: 7, P: 1-12
Release of linker histone from the nucleosome driven by polyelectrolyte competition with a disordered protein

Histone H1 binds to nucleosomes with ultrahigh affinity, implying residence times incompatible with efficient biological regulation. Now it has been shown that the disordered regions of H1 retain their large-amplitude dynamics on the nucleosome, which enables a charged disordered histone chaperone to invade the H1–nucleosome complex and vastly accelerate H1 dissociation.

Pétur O. Heidarsson
Davide Mercadante
Benjamin Schuler
Research06 Jan 2022
Nature Chemistry

Volume: 14, P: 224-231
Polyelectrolyte interactions enable rapid association and dissociation in high-affinity disordered protein complexes

The intrinsically disordered linker histone H1.0 and prothymosin α form a complex which exhibits slow exchange between bound and unbound populations at low protein concentrations and fast exchange at high concentrations. Here authors explain this observation by the formation of transient ternary complexes favored at high protein concentrations that accelerate the exchange.

Andrea Sottini
Alessandro Borgia
Benjamin Schuler
ResearchOpen Access12 Nov 2020
Nature Communications

Volume: 11, P: 1-14
Correction: Corrigendum: Fast native-SAD phasing for routine macromolecular structure determination

Tobias Weinert
Vincent Olieric
Meitian Wang
Amendments and Corrections30 Jun 2015
Nature Methods

Volume: 12, P: 692
Deconvolution of Buparlisib’s mechanism of action defines specific PI3K and tubulin inhibitors for therapeutic intervention

Buparlisib/BKM120 is in phase 3 clinical trials as a phosphoinositide 3-kinase (PI3K) inhibitor. Here, Bohnackeret al. combine chemical biology and structural biology approaches to segregate BKM120’s biological actions, and suggest that it causes mitotic arrest predominantly by binding microtubules and disrupting their dynamics.

Thomas Bohnacker
Andrea E. Prota
Matthias P. Wymann
ResearchOpen Access09 Mar 2017
Nature Communications

Volume: 8, P: 1-13
A fluorescence anisotropy assay to discover and characterize ligands targeting the maytansine site of tubulin

Microtubule-targeting agents are used successfully as anticancer therapeutics. Here authors develop a fluorescence-anisotropy-based assay to identify and characterize ligands for the maytansine site of tubulin and provide crystal structures of identified ligands in complex with tubulin.

Grégory Menchon
Andrea E. Prota
Michel O. Steinmetz
ResearchOpen Access29 May 2018
Nature Communications

Volume: 9, P: 1-9
Sustainable Syntheses of (−)-Jerantinines A & E and Structural Characterisation of the Jerantinine-Tubulin Complex at the Colchicine Binding Site

Christopher J. Smedley
Paul A. Stanley
John E. Moses
ResearchOpen Access13 Jul 2018
Scientific Reports

Volume: 8, P: 1-7
Seismic resilience of urban networks: dataset for infrastructure visualization and vulnerability assessment

Marco Civera
Fabrizio Aloschi
Andrea Prota
ResearchOpen Access03 Oct 2025
Scientific Data

Volume: 12, P: 1-16
Serial millisecond crystallography for routine room-temperature structure determination at synchrotrons

Serial crystallography was developed for protein crystal data collection with X-ray free-electron lasers. Here the authors present several examples which show that serial crystallography using high-viscosity injectors can also be routinely employed for room-temperature data collection at synchrotrons.

Tobias Weinert
Natacha Olieric
Jörg Standfuss
ResearchOpen Access14 Sept 2017
Nature Communications

Volume: 8, P: 1-11
Bioprospecting on invasive plant species to prevent seed dispersal

Lorenzo Guzzetti
Andrea Galimberti
Massimo Labra
ResearchOpen Access23 Oct 2017
Scientific Reports

Volume: 7, P: 1-11
DNA damage-induced cell-cycle phase regulation of p53 and p21^waf1 in normal and ATM-defective cells

Domenico Delia
Enrico Fontanella
Shuki Mizutani
Research30 Oct 2003
Oncogene

Volume: 22, P: 7866-7869
Fast native-SAD phasing for routine macromolecular structure determination

A native-SAD (single-wavelength anomalous diffraction) data collection strategy enables phasing using anomalous signal from a single native crystal, facilitating straightforward macromolecular X-ray structure determination.

Tobias Weinert
Vincent Olieric
Meitian Wang
Research15 Dec 2014
Nature Methods

Volume: 12, P: 131-133
Effect of buoyancy loads on the tsunami fragility of existing reinforced concrete frames including consideration of blow-out slabs

Marta Del Zoppo
Tiziana Rossetto
Andrea Prota
ResearchOpen Access02 Jun 2023
Scientific Reports

Volume: 13, P: 1-17
Structural basis of katanin p60:p80 complex formation

Lenka Rezabkova
Kai Jiang
Richard A. Kammerer
ResearchOpen Access02 Nov 2017
Scientific Reports

Volume: 7, P: 1-8
High-affinity ligands of the colchicine domain in tubulin based on a structure-guided design

Oskía Bueno
Juan Estévez Gallego
Eva-María Priego
ResearchOpen Access09 Mar 2018
Scientific Reports

Volume: 8, P: 1-17
Determinants of loss to care and risk of clinical progression in PLWH who are re-engaged in care after a temporary loss

Cristina Mussini
Patrizia Lorenzini
Enrico Girardi
ResearchOpen Access05 May 2021
Scientific Reports

Volume: 11, P: 1-13

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