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Showing 1–10 of 10 results
Advanced filters: Author: Andrea L Bredemeyer Clear advanced filters

  • As part of the response to exogenous DNA damage, the transcription of certain genes involved in cell cycle checkpoints and survival is affected; these changes help the cell to maintain its genomic integrity. There are also situations in which endogenous, physiological DNA double-strand breaks occur. This paper shows that the breaks which initiate the rearrangement of antigen receptor genes also activate a transcriptional program, but with a difference. Many of the regulated genes are involved in lymphocyte development.

    • Andrea L. Bredemeyer
    • Beth A. Helmink
    • Barry P. Sleckman
    Research
    Nature
    Volume: 456, P: 819-823

  • A fibroblast lineage marked by FAP gives rise to POSTN-expressing fibroblasts resembling matrifibrocytes and IL-1β regulates FAP/POSTN fibroblast specification by directly signalling to cardiac fibroblasts, highlighting a role for immunomodulators in targeting cardiac fibrosis.

    • Junedh M. Amrute
    • Xin Luo
    • Kory J. Lavine
    Research
    Nature
    Volume: 635, P: 423-433

  • Time- and tissue-specific recombination of antigen-receptor genes is regulated in part by locus accessibility. New evidence demonstrates a specific function for nucleosome remodeling in the T cell receptor-β locus to allow recombination in thymocytes.

    • Andrea L Bredemeyer
    • Barry P Sleckman
    News & Views
    Nature Immunology
    Volume: 8, P: 795-796

  • Examination of the role of the ATM protein in oncogenic chromosomal translocations in the disease ataxia telangiectasia finds that ATM is involved directly in stabilizing a complex that occurs when DNA double-strand breaks are made in lymphocyte antigen receptor loci. When the complex is not stabilized, the DNA ends are able to undergo aberrant reactions that can lead to translocations.

    • Andrea L. Bredemeyer
    • Girdhar G. Sharma
    • Barry P. Sleckman
    Research
    Nature
    Volume: 442, P: 466-470

  • Amrute, Lai et al. performed single-nucleus RNA sequencing and compared the cellular and transcriptomic features of hearts from non-diseased donors, from patients with heart failure who recovered systolic function after left ventricular assist device implantation and from patients who did not recover. The analyses identified cell-type-specific signatures of recovery and revealed the downregulation of RUNX1 expression in macrophages and fibroblasts as a predictor of recovery, as confirmed by in silico simulations and re-analysis of data from a mouse model of cardiac functional recovery.

    • Junedh M. Amrute
    • Lulu Lai
    • Kory J. Lavine
    Research
    Nature Cardiovascular Research
    Volume: 2, P: 399-416

  • Koenig et al. present integrated single-cell and single-nucleus RNA-sequencing data of cardiac samples obtained from 27 healthy donors and 18 individuals with dilated cardiomyopathy. This extensive resource provides insights on cell composition and gene expression changes driven by the disease status, sex or age of the patients.

    • Andrew L. Koenig
    • Irina Shchukina
    • Kory J. Lavine
    ResearchOpen Access
    Nature Cardiovascular Research
    Volume: 1, P: 263-280