Nature Search

LRF maintains genome integrity by regulating the non-homologous end joining pathway of DNA repair

Leukemia/lymphoma-related factor (LRF), a transcriptional repressor, plays key roles in cell fate decision and tumorigenesis. Here, Liu et al. show that LRF loss results in defective classical non-homologous end joining, genomic instability and hypersensitivity to ionizing radiation, revealing a transcription-independent regulation of DNA-PK complex.

Xue-Song Liu
Gurushankar Chandramouly
Pier Paolo Pandolfi
ResearchOpen Access08 Oct 2015
Nature Communications

Volume: 6, P: 1-10
Increased ectodysplasin-A2-receptor EDA2R is a ubiquitous hallmark of aging and mediates parainflammatory responses

In a broad cross-tissue analysis, the authors show that a receptor called EDA2R steadily increases with age in both humans and animal models, and becomes even more active in conditions like obesity and diabetes, intensifying inflammation-like processes in muscle cells.

Maria Chiara Barbera
Luca Guarrera
Marco Bolis
ResearchOpen Access23 Feb 2025
Nature Communications

Volume: 16, P: 1-11
Zbtb7a suppresses prostate cancer through repression of a Sox9-dependent pathway for cellular senescence bypass and tumor invasion

The transcription factor Zbtb7a was previously described as an oncogene in non-Hodgkin lymphoma. Now, Pier Paolo Pandolfi and colleagues report that loss of Zbtb7a accelerates the progression of invasive prostate tumorigenesis in Pten-null mice and shows evidence of monoallelic loss in 18% of individuals with advanced prostate cancer.

Guocan Wang
Andrea Lunardi
Pier Paolo Pandolfi
Research02 Jun 2013
Nature Genetics

Volume: 45, P: 739-746
Body mass index and circulating oestrone sulphate in women treated with adjuvant letrozole

V Sini
G Lunardi
L Del Mastro
ResearchOpen Access21 Jan 2014
British Journal of Cancer

Volume: 110, P: 1133-1138
CSL controls telomere maintenance and genome stability in human dermal fibroblasts

Conversion of dermal fibroblasts into Cancer Associated Fibroblasts (CAFs) can play an important role in keratinocyte tumour development. Here the authors reveal that CSL plays a role in maintenance of telomeres and genomic integrity in both dermal fibroblasts and CAFs.

Giulia Bottoni
Atul Katarkar
G. Paolo Dotto
ResearchOpen Access29 Aug 2019
Nature Communications

Volume: 10, P: 1-15
Author Correction: A co-clinical approach identifies mechanisms and potential therapies for androgen deprivation resistance in prostate cancer

Andrea Lunardi
Ugo Ala
Pier Paolo Pandolfi
Amendments and Corrections03 Sept 2020
Nature Genetics

Volume: 52, P: 1132
Modeling medulloblastoma in vivo and with human cerebellar organoids

Group 3 medulloblastoma (MB) is considered one of the most aggressive forms of this cancer. Here, the authors show that Otx2 and c-MYC oncogenes can drive Group 3 MB formation in mouse and human cerebellar organoids while SMARCA4 overexpression or a EZH2-specific inhibitor can inhibit tumorigenesis.

Claudio Ballabio
Marica Anderle
Luca Tiberi
ResearchOpen Access29 Jan 2020
Nature Communications

Volume: 11, P: 1-18
A co-clinical approach identifies mechanisms and potential therapies for androgen deprivation resistance in prostate cancer

Pier Paolo Pandolfi and colleagues report that compound loss of Pten with Zbtb7a or Trp53 leads to de novo resistance to androgen deprivation therapy in prostate cancer. Integrative analysis of mouse and human data in a co-clinical approach identified XIAP and SRD5A1 inhibitors as potential therapies for castration-resistant prostate cancer.

Andrea Lunardi
Ugo Ala
Pier Paolo Pandolfi
Research02 Jun 2013
Nature Genetics

Volume: 45, P: 747-755
Diverse genetic-driven immune landscapes dictate tumor progression through distinct mechanisms

Pier Paolo Pandolfi and colleagues report that the genetic background of tumors in mice recruits specific immune-cell subsets, suggesting that precision medicine should account for both the tumor drivers and the distinct immune-cell microenvironments that they elicit.

Marco Bezzi
Nina Seitzer
Pier Paolo Pandolfi
Research08 Jan 2018
Nature Medicine

Volume: 24, P: 165-175
Calcium cytotoxicity sensitizes prostate cancer cells to standard-of-care treatments for locally advanced tumors

Alessandro Alaimo
Marco Lorenzoni
Andrea Lunardi
ResearchOpen Access07 Dec 2020
Cell Death & Disease

Volume: 11, P: 1-17
Primary coenzyme Q₁₀ deficiency presenting as fatal neonatal multiorgan failure

Maria Andrea Desbats
Annalisa Vetro
Leonardo Salviati
Research07 Jan 2015
European Journal of Human Genetics

Volume: 23, P: 1254-1258

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