Advanced search

Filter By:

Journal Check one or more journals to show results from those journals only.

Choose more journals

Article type Check one or more article types to show results from those article types only.
Subject Check one or more subjects to show results from those subjects only.
Date Choose a date option to show results from those dates only.

Custom date range

Clear all filters
Sort by:
Showing 1–5 of 5 results
Advanced filters: Author: Andrea Pavia-Jimenez Clear advanced filters

  • Somasekar Seshagiri, James Brugarolas and colleagues report the mutational landscape of 167 non–clear cell renal cell carcinomas (nccRCCs) from multiple subtypes. They identify subtype-specific driver mutations and gene fusions, including ones involving MITF, which result in expression of the anti-apoptotic protein BIRC7 and might thus indicate candidates for treatment with BIRC7 inhibitors.

    • Steffen Durinck
    • Eric W Stawiski
    • Somasekar Seshagiri
    Research
    Nature Genetics
    Volume: 47, P: 13-21

  • James Brugarolas and colleagues identify recurrent BAP1 mutations in clear cell renal cell carcinoma (ccRCC). They show that BAP1 binds to HCF-1 and suppresses cell proliferation, and they find that BAP1 loss is associated with high tumor grade.

    • Samuel Peña-Llopis
    • Silvia Vega-Rubín-de-Celis
    • James Brugarolas
    Research
    Nature Genetics
    Volume: 44, P: 751-759

  • The HIF-2 antagonist PT2399 is tested in mice bearing tumourgrafts derived from human renal cell cancers to demonstrate its efficacy, identify markers of sensitivity and characterize its effects.

    • Wenfang Chen
    • Haley Hill
    • James Brugarolas
    Research
    Nature
    Volume: 539, P: 112-117