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Showing 1–4 of 4 results
Advanced filters: Author: Andrea Ponzetta Clear advanced filters

  • Here the authors map the dynamics of human NK cell residency and recirculation, showing that CD56bright NK cells transiently occupy tissues and recirculate via lymphatics, whereas CD56dim NK cells remain vascular except during inflammation.

    • Annika Niehrs
    • Laura Hertwig
    • Niklas K. Björkström
    ResearchOpen Access
    Nature Immunology
    Volume: 26, P: 2004-2015

  • Interleukin-1 receptor 8 (IL-1R8), a negative regulator of the IL-1 family of cytokines, restrains the activity of natural killer (NK) cells, suggesting that IL-1R8 acts as a checkpoint regulator of NK cell activation and that its blockade may be of use in cancer therapy.

    • Martina Molgora
    • Eduardo Bonavita
    • Alberto Mantovani
    Research
    Nature
    Volume: 551, P: 110-114

  • This Review discusses the emerging dual role played by neutrophils in the tumour microenvironment as part of tumour-promoting inflammation, while also mediating antitumour immune responses, and suggests that neutrophil function could be manipulated in myeloid cell-based therapeutic approaches to improve patient outcomes.

    • Sebastien Jaillon
    • Andrea Ponzetta
    • Alberto Mantovani
    Reviews
    Nature Reviews Cancer
    Volume: 20, P: 485-503