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Discovery of a paralog-selective p300 protein degrader with potent anti-cancer activity in hematological malignancies

This study reports a paralog-selective p300 degrader with potent anti-cancer activity in hematological malignancies, demonstrating a strategy to selectively target transcriptional coactivators through protein degradation.

Marwa S. Asem
Yan Zhai
Jurgen Dinges
ResearchOpen Access06 May 2026
Nature Communications

P: 1-16

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Discovery of a paralog-selective p300 protein degrader with potent anti-cancer activity in hematological malignancies

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