Secretory cells are major constituents of the lung airways, but their diversity, organization and specification are partially understood. Here, single-cell analysis reveals a differentiation gradient: proximal airway regions specialize in innate immunity, distal regions in lipid metabolism, while intermediate cells express low levels of both programs, driven by Fgfr2 signaling.
- Alexandros Sountoulidis
- Jonas Theelke
- Christos Samakovlis
