Advanced search

Filter By:

Journal Check one or more journals to show results from those journals only.

Choose more journals

Article type Check one or more article types to show results from those article types only.
Subject Check one or more subjects to show results from those subjects only.
Date Choose a date option to show results from those dates only.

Custom date range

Clear all filters
Sort by:
Showing 1–14 of 14 results
Advanced filters: Author: Andreas Brech Clear advanced filters

  • Intraluminal vesicles are formed by the endosomal sorting complex required for transport (ESCRT) machinery. Here, the authors unravel the timing of vesicle budding, and that endosomal clathrin regulates concerted recruitment of ESCRT subcomplexes, required for efficient membrane remodeling.

    • Eva Maria Wenzel
    • Sebastian Wolfgang Schultz
    • Camilla Raiborg
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-18

  • The matrix metalloprotease MT1-MMP drives cancer metastasis. Here, the authors demonstrate how invasive cancer cells instigate non-invasive neighbouring cells to become degradative and invasive by transferring catalytically active MT1-MMP fragments.

    • Eva Maria Wenzel
    • Nina Marie Pedersen
    • Camilla Raiborg
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-22

  • γδ T cells are unique T lymphocytes with cytotoxic functions, targeting infections and tumours. Here authors show that the target killing function of γδ T cells is tightly regulated at the level of the availability of lytic molecules granzyme B and perforin.

    • Patrick A. Sandoz
    • Kyra Kuhnigk
    • Björn Önfelt
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-16

  • Natural killer (NK) cells are functionally calibrated against self MHC during a process termed education. Here the authors show that NK cell education is associated with the accumulation of dense-core secretory lysosomes for expedited release of granzyme B and Ca2+ flux upon target recognition and NK cell activation.

    • Jodie P. Goodridge
    • Benedikt Jacobs
    • Karl-Johan Malmberg
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-15

  • A theoretical model, in vitro reconstitution and in vivo experimentation show that competition between droplet surface tension and membrane sheet instability dictates the form and function of autophagosomal membranes.

    • Jaime Agudo-Canalejo
    • Sebastian W. Schultz
    • Roland L. Knorr
    Research
    Nature
    Volume: 591, P: 142-146

  • PB1-mediated oligomerization of p62/SQSTM1 is essential for its function as a selective autophagy receptor. Here the authors present the cryo-EM structures of human and Arabidopsis PB1 domain helical assemblies and find that a conserved double arginine finger in the PB1 domain is important for p62 polymerisation and lysosomal targeting of p62.

    • Arjen J. Jakobi
    • Stefan T. Huber
    • Carsten Sachse
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-15

  • Centrosomes drive mitotic spindle formation and chromosome segregation. Here, the authors show that centrosome stability is regulated by selective autophagic degradation of centriolar satellite components in a process they term doryphagy, connecting autophagy and chromosomal integrity.

    • Søs Grønbæk Holdgaard
    • Valentina Cianfanelli
    • Francesco Cecconi
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-19

  • Defects in non-canonical Wnt/planar cell polarity signalling have recently been linked to breast cancer aggressiveness. Puvirajesinghe et al. identify VANGL2, p62/SQSTM1 and JNK as important players in this pathway which may be amenable to therapeutic intervention in breast cancer.

    • Tania M. Puvirajesinghe
    • François Bertucci
    • Jean-Paul Borg
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-15

  • During early-stage tumour growth in Drosphila, tumour cells acquire necessary nutrients by triggering autophagy in surrounding cells in the tumour microenvironment.

    • Nadja S. Katheder
    • Rojyar Khezri
    • Tor Erik Rusten
    Research
    Nature
    Volume: 541, P: 417-420

  • Repeated contacts between the endoplasmic reticulum (ER) and a subset of endosomes called late endosomes (LEs) is shown to promote microtubule-dependent translocation of LEs to the cell periphery and their subsequent fusion with the plasma membrane to induce outgrowth of neuronal protrusions.

    • Camilla Raiborg
    • Eva M. Wenzel
    • Harald Stenmark
    Research
    Nature
    Volume: 520, P: 234-238