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Showing 1–4 of 4 results
Advanced filters: Author: Andreas Brunschweiger Clear advanced filters

  • Encoded libraries of synthetic macrocycles generated by ring-closing metathesis (RCM) hold significant potential to address conventionally undruggable targets, but the application of RCM to oligonucleotide-conjugated systems has been restricted. Here, authors report the synthesis of nucleic acid-tagged macrocycles via RCM in neat water, using an anionic, water-soluble ruthenium catalyst.

    • Chun Zhang
    • Christian O. Blanco
    • Andreas Brunschweiger
    ResearchOpen Access
    Nature Communications
    P: 1-12

  • Validation of the cellular targets of microRNAs remains an ongoing priority. miR-CLIP, a new method based on psoralen crosslinking, immunoprecipitation and biotin affinity pulldowns, was applied to determine the miR-106a targetome, which included the H19 lncRNA.

    • Jochen Imig
    • Andreas Brunschweiger
    • Jonathan Hall
    Research
    Nature Chemical Biology
    Volume: 11, P: 107-114

  • Lin28 prevents the processing of pre-let-7 RNAs, but it is not clear where the Lin28 RNA binding domains interact with the RNA. The NMR structure of the Lin28 zinc knuckles with a short RNA motif reveals that each knuckle interacts with an AG dinucleotide, allowing the determination of a consensus motif for pre-let-7 recognition.

    • Fionna E Loughlin
    • Luca F R Gebert
    • Frédéric H-T Allain
    Research
    Nature Structural & Molecular Biology
    Volume: 19, P: 84-89

  • DNA-encoded chemical libraries (DECLs) are used in the discovery of small molecules with potential therapeutic benefit. In this Primer, Satz et al. describe the best practices for DECL synthesis, selection and analysis, as well as requirements to enhance reproducibility between and within groups.

    • Alexander L. Satz
    • Andreas Brunschweiger
    • Jörg Scheuermann
    Reviews
    Nature Reviews Methods Primers
    Volume: 2, P: 1-17