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Showing 1–3 of 3 results
Advanced filters: Author: Andreas M. Küffner Clear advanced filters

  • Auxotrophic metabolic sensors (AMS) are vital for bioengineering but are often time-consuming to develop. Here, the authors present a workflow for designing versatile AMS, demonstrating their use for sensing glyoxylate and glycolate, with applications in pathway engineering and environmental monitoring.

    • Enrico Orsi
    • Helena Schulz-Mirbach
    • Pablo I. Nikel
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-16

  • One-carbon compounds, including carbon dioxide and methane, represent a sustainable resource for chemical conversions. This Review highlights recent advances in the biochemical upgrading of one-carbon substrates to value-added products using a combination of cellular, cell-free and abiotic catalysis strategies.

    • Blake J. Rasor
    • Simone Giaveri
    • Tobias J. Erb
    Reviews
    Nature Synthesis
    Volume: 4, P: 787-798

  • Understanding of the molecular mechanisms underlying the maturation of protein condensates into amyloid fibrils associated with neurodegenerative diseases has so far remained elusive. Now it has been shown that in condensates formed by the low-complexity domain of the amyotrophic lateral sclerosis-associated protein hnRNPA1, fibril formation is promoted at the interface, which provides a potential therapeutic target for counteracting aberrant protein aggregation.

    • Miriam Linsenmeier
    • Lenka Faltova
    • Paolo Arosio
    ResearchOpen Access
    Nature Chemistry
    Volume: 15, P: 1340-1349