Nature Search

Potentially bioavailable iron produced through benthic cycling in glaciated Arctic fjords of Svalbard

The impacts of a melting Arctic on the biogeochemistry of marine ecosystems are unknown. Here, the authors investigate glacial input of iron to Svalbard fjords finding that reworking of glacial iron in fjord sediment is important to make iron bioavailable, but could be susceptible to glacial retreat.

Katja Laufer-Meiser
Alexander B. Michaud
Bo Barker Jørgensen
ResearchOpen Access01 Mar 2021
Nature Communications

Volume: 12, P: 1-13
Chemical unclonable functions based on operable random DNA pools

Physical unclonable functions provide algorithm-independent cryptography based on non-distributable unique tokens. Here, the authors introduce unclonable functions based on random DNA pools, enabling secure decentralized authentication.

Anne M. Luescher
Andreas L. Gimpel
Robert N. Grass
ResearchOpen Access05 Apr 2024
Nature Communications

Volume: 15, P: 1-11
The role of CXCR3/LRP1 cross-talk in the invasion of primary brain tumors

The chemokine receptor CXCR3-A is expressed in high grade glioma. Here the authors show that CXCR3-A interacts with LPR1, a protein highly expressed in glioma, and this interaction regulates the trafficking of the receptor ultimately impacting on tumour cell migration.

Kevin Boyé
Nadège Pujol
Clotilde Billottet
ResearchOpen Access17 Nov 2017
Nature Communications

Volume: 8, P: 1-20
Pharmacological targeting of MTHFD2 suppresses acute myeloid leukemia by inducing thymidine depletion and replication stress

Helleday and colleagues describe a nanomolar MTHFD2 inhibitor that causes replication stress and DNA damage accumulation in cancer cells via thymidine depletion, demonstrating a potential therapeutic strategy in AML tumors in vivo.

Nadilly Bonagas
Nina M. S. Gustafsson
Thomas Helleday
ResearchOpen Access28 Feb 2022
Nature Cancer

Volume: 3, P: 156-172
GAP43-dependent mitochondria transfer from astrocytes enhances glioblastoma tumorigenicity

Watson et al. demonstrate that astrocyte mitochondria can be horizontally transferred to glioblastoma cells in a GAP43-dependent manner, leading to changes in mitochondrial respiration and metabolism that promote proliferation and tumor growth.

Dionysios C. Watson
Defne Bayik
Justin D. Lathia
ResearchOpen Access11 May 2023
Nature Cancer

Volume: 4, P: 648-664
Fine-mapping of 150 breast cancer risk regions identifies 191 likely target genes

Fine-mapping of causal variants and integration of epigenetic and chromatin conformation data identify likely target genes for 150 breast cancer risk regions.

Laura Fachal
Hugues Aschard
Alison M. Dunning
Research07 Jan 2020
Nature Genetics

Volume: 52, P: 56-73
Population pharmacokinetic modeling of multiple-dose intravenous fosfomycin in critically ill patients during continuous venovenous hemodialysis

Tobias Hüppe
Katharina M. Götz
Sascha Kreuer
ResearchOpen Access24 Oct 2023
Scientific Reports

Volume: 13, P: 1-13
Early intervention with azelastine nasal spray may reduce viral load in SARS-CoV-2 infected patients

Jens Peter Klussmann
Maria Grosheva
Ralph Mösges
ResearchOpen Access26 Apr 2023
Scientific Reports

Volume: 13, P: 1-12
Information decay and enzymatic information recovery for DNA data storage

An enzymatic repair system is described which repairs nicked DNA in DNA libraries, and simulations of damage and repair suggests this enzymatic repair step is beneficial for DNA data storage.

Linda C. Meiser
Andreas L. Gimpel
Robert N. Grass
ResearchOpen Access20 Oct 2022
Communications Biology

Volume: 5, P: 1-9
Impact of rapid genetic counselling and testing on the decision to undergo immediate or delayed prophylactic mastectomy in newly diagnosed breast cancer patients: findings from a randomised controlled trial

M R Wevers
N K Aaronson
M G E M Ausems
ResearchOpen Access14 Jan 2014
British Journal of Cancer

Volume: 110, P: 1081-1087
FANCM missense variants and breast cancer risk: a case-control association study of 75,156 European women

Gisella Figlioli
Amandine Billaud
Paolo Peterlongo
ResearchOpen Access27 Jan 2023
European Journal of Human Genetics

Volume: 31, P: 578-587

Search

Potentially bioavailable iron produced through benthic cycling in glaciated Arctic fjords of Svalbard

Chemical unclonable functions based on operable random DNA pools

The role of CXCR3/LRP1 cross-talk in the invasion of primary brain tumors

Pharmacological targeting of MTHFD2 suppresses acute myeloid leukemia by inducing thymidine depletion and replication stress

GAP43-dependent mitochondria transfer from astrocytes enhances glioblastoma tumorigenicity

Fine-mapping of 150 breast cancer risk regions identifies 191 likely target genes

Population pharmacokinetic modeling of multiple-dose intravenous fosfomycin in critically ill patients during continuous venovenous hemodialysis

Early intervention with azelastine nasal spray may reduce viral load in SARS-CoV-2 infected patients

Information decay and enzymatic information recovery for DNA data storage

Impact of rapid genetic counselling and testing on the decision to undergo immediate or delayed prophylactic mastectomy in newly diagnosed breast cancer patients: findings from a randomised controlled trial

FANCM missense variants and breast cancer risk: a case-control association study of 75,156 European women

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