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Accumulation of mutations in antibody and CD8 T cell epitopes in a B cell depleted lymphoma patient with chronic SARS-CoV-2 infection

SARS-CoV-2 mutations associated with the escape from antibody-mediated neutralization have been widely reported. Here, in a patient with defective antibody responses, the authors find a potential association between SARS-CoV-2 mutations and CD8 T alterations to implicate possible contributions of CD8 T cells in evasion of SARS-CoV-2 from host immunity.

Elham Khatamzas
Markus H. Antwerpen
Andreas Moosmann
ResearchOpen Access23 Sept 2022
Nature Communications

Volume: 13, P: 1-12
Potent high-avidity neutralizing antibodies and T cell responses after COVID-19 vaccination in individuals with B cell lymphoma and multiple myeloma

Keppler and colleagues show that individuals with hematological cancers rapidly develop potent infection-neutralizing antibodies and a robust T cell response against several SARS-CoV-2 variants of concern in response to mRNA vaccination.

Andrea Keppler-Hafkemeyer
Christine Greil
Oliver T. Keppler
ResearchOpen Access21 Dec 2022
Nature Cancer

Volume: 4, P: 81-95
Epstein-Barr virus-driven B cell lymphoma mediated by a direct LMP1-TRAF6 complex

Epstein-Barr virus causes lymphoma. Here the authors describe a direct complex of the viral oncoprotein LMP1 with the cellular TRAF6 protein as a critical virus-host interface for lymphoma survival and validate this complex as a potential therapeutic target.

Fabian Giehler
Michael S. Ostertag
Arnd Kieser
ResearchOpen Access10 Jan 2024
Nature Communications

Volume: 15, P: 1-18
A central role of IKK2 and TPL2 in JNK activation and viral B-cell transformation

IKK2 is the main mediator of the NF-kappaB pathway. Here, the authors demonstrate that LMP1 sustains the survival of Epstein-Barr virus-transformed human B cells and post-transplant lymphoma through IKK2 that induces JNK signaling through TPL2.

Stefanie Voigt
Kai R. Sterz
Arnd Kieser
ResearchOpen Access04 Feb 2020
Nature Communications

Volume: 11, P: 1-16
Feasibility, classification and potential clinical impact of non-invasive delineation of abdominal lymphatic vessels in patients following TCPC with T2 weighted MRI

Anja Hanser
Michael Hofbeck
Ludger Sieverding
ResearchOpen Access29 Nov 2024
Scientific Reports

Volume: 14, P: 1-11
The selective degradation of sirtuins via macroautophagy in the MPP⁺ model of Parkinson’s disease is promoted by conserved oxidation sites

Marius W. Baeken
Mario Schwarz
Christian Behl
ResearchOpen Access12 Oct 2021
Cell Death Discovery

Volume: 7, P: 1-11
Neutrophils mediate early cerebral cortical hypoperfusion in a murine model of subarachnoid haemorrhage

Axel Neulen
Tobias Pantel
Serge C. Thal
ResearchOpen Access11 Jun 2019
Scientific Reports

Volume: 9, P: 1-10

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Accumulation of mutations in antibody and CD8 T cell epitopes in a B cell depleted lymphoma patient with chronic SARS-CoV-2 infection

Potent high-avidity neutralizing antibodies and T cell responses after COVID-19 vaccination in individuals with B cell lymphoma and multiple myeloma

Epstein-Barr virus-driven B cell lymphoma mediated by a direct LMP1-TRAF6 complex

A central role of IKK2 and TPL2 in JNK activation and viral B-cell transformation

Feasibility, classification and potential clinical impact of non-invasive delineation of abdominal lymphatic vessels in patients following TCPC with T2 weighted MRI

The selective degradation of sirtuins via macroautophagy in the MPP+ model of Parkinson’s disease is promoted by conserved oxidation sites

Neutrophils mediate early cerebral cortical hypoperfusion in a murine model of subarachnoid haemorrhage

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The selective degradation of sirtuins via macroautophagy in the MPP⁺ model of Parkinson’s disease is promoted by conserved oxidation sites