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Showing 1–7 of 7 results
Advanced filters: Author: Andreas S. Puschnik Clear advanced filters

  • Sunshine et al. use Perturb-seq to study host dependencies of SARS-CoV-2 by inactivating host factors genetically and monitoring the course of infection by single-cell sequencing, characterizing global host phenotypes. They identified NFKBIA, EIF4E2 and EIF4H as strong host dependency factors.

    • Sara Sunshine
    • Andreas S. Puschnik
    • Marco Y. Hein
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-13

  • In this Review, Puschnik and colleagues discuss the technical aspects of using CRISPR–Cas technology in genome-scale knockout screens to study virus–host interactions, and they compare these screens with alternative genetic screening technologies.

    • Andreas S. Puschnik
    • Karim Majzoub
    • Jan E. Carette
    Reviews
    Nature Reviews Microbiology
    Volume: 15, P: 351-364

  • A survey of the cellular RNA-binding proteins (RBPs) that interact with dengue virus and Zika virus genomic RNA identifies ribosome-binding protein 1 and vigilin as bona fide RBPs able to promote viral RNA translation, replication and stability.

    • Yaw Shin Ooi
    • Karim Majzoub
    • Jan E. Carette
    Research
    Nature Microbiology
    Volume: 4, P: 2369-2382

  • A CRISPR screening approach shows that endoplasmic reticulum (ER)-associated protein complexes, including the oligosaccharyltransferase (OST) protein complex, are important for infection by dengue virus and other related mosquito-borne flaviviruses, whereas hepatitis C virus is dependent on distinct entry factors, RNA binding proteins and FAD biosynthesis.

    • Caleb D. Marceau
    • Andreas S. Puschnik
    • Jan E. Carette
    Research
    Nature
    Volume: 535, P: 159-163