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Showing 1–2 of 2 results
Advanced filters: Author: Andreas Tiffeau-Mayer Clear advanced filters
  • Across biological subdisciplines, the last decade has seen an explosion of high-dimensional datasets. At the ICTS workshop ‘Unifying Theories in High-Dimensional Biophysics’, we discussed whether this high dimensionality poses a challenge or an opportunity for theoretically describing, understanding and predicting biological systems. We discussed methods, models and frameworks that can be used for this purpose. This Comment summarizes our discussions from the perspectives of individual participants.

    • Marianne Bauer
    • Akshit Goyal
    • Suriyanarayanan Vaikuntanathan
    Comments & OpinionOpen Access
    npj Systems Biology and Applications
    Volume: 12, P: 1-10
  • T cells contribute to protection and pathogenesis in tuberculosis. Here the authors sequence T cell receptor repertoires in human skin biopsies from the site of the tuberculin skin test and show enrichment of clonotypes reactive to Mycobacterium tuberculosis using a computational pipeline metaclonotypist to identify distinct TCRs predicted to share peptide-MHC reactivity across participants, as an approach to explore T cell correlates of tuberculosis disease-risk stratification and vaccine efficacy.

    • Carolin T. Turner
    • Andreas Tiffeau-Mayer
    • Mahdad Noursadeghi
    ResearchOpen Access
    Nature Communications
    Volume: 17, P: 1-16