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Showing 1–6 of 6 results
Advanced filters: Author: Andrei E. Tarkhov Clear advanced filters

  • At single-cell resolution, Tarkhov et al. delineate stochastic and co-regulated components of epigenetic aging, revealing a simultaneous loss of regulation at the epigenetic and transcriptional levels in aging.

    • Andrei E. Tarkhov
    • Thomas Lindstrom-Vautrin
    • Vadim N. Gladyshev
    Research
    Nature Aging
    Volume: 4, P: 854-870

  • Aging is associated with an increased risk of chronic diseases and functional decline. Here, the authors investigate the fluctuations of physiological indices along aging trajectories and observed a characteristic decrease in the organism state recovery rate.

    • Timothy V. Pyrkov
    • Konstantin Avchaciov
    • Peter O. Fedichev
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-10

  • Biomarkers of age and frailty may aid in understanding the aging process, predicting lifespan or health span and in assessing the effects of anti-aging interventions. Here, the authors show that combining physics-based models and deep learning may enhance understanding of aging from big biomedical data, observe effects of anti-aging interventions in laboratory animals, and discover signatures of longevity.

    • Konstantin Avchaciov
    • Marina P. Antoch
    • Peter O. Fedichev
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-14

  • DNA methylation (DNAm) is a key biomarker of aging, with age-related DNAm changes being well-characterized. Here, the authors show that low-methylated regions (LMRs) bound by PRC2 in embryonic stem cells gain methylation with age in somatic cells, proposing the “PRC2-AgeIndex” as a universal biomarker of cellular aging.

    • Mahdi Moqri
    • Andrea Cipriano
    • Vittorio Sebastiano
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-12

  • The authors identify causality-enriched CpGs linked to aging using Mendelian randomization. They develop new epigenetic clocks, DamAge and AdaptAge, that more reliably track age-related changes, offering insights into aging mechanisms and interventions.

    • Kejun Ying
    • Hanna Liu
    • Vadim N. Gladyshev
    Research
    Nature Aging
    Volume: 4, P: 231-246