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Cholesterol-mediated allosteric regulation of the mitochondrial translocator protein structure

The outer mitochondrial membrane translocator protein (TSPO) mediates several mitochondrial functions and binds cholesterol with a high affinity. Here the authors use solid-state NMR to show that cholesterol binding to TSPO results in allosteric changes that modulate TSPO oligomerization.

Garima Jaipuria
Andrei Leonov
Markus Zweckstetter
ResearchOpen Access30 Mar 2017
Nature Communications

Volume: 8, P: 1-8
Anle138b binds predominantly to the central cavity in lipidic Aβ₄₀ fibrils and modulates fibril formation

This study characterizes the interaction between the clinical candidate anle138b and Aβ₄₀ fibrils in a lipid environment. The compound reduced fibril formation by approximately 75%, providing insights relevant to Alzheimer’s drug development.

Mookyoung Han
Benedikt Frieg
Christian Griesinger
ResearchOpen Access03 Oct 2025
Nature Communications

Volume: 16, P: 1-17
The clinical drug candidate anle138b binds in a cavity of lipidic α-synuclein fibrils

Understanding how small molecules bind to pathological aggregates is of importance for therapeutic and diagnostic development in diseases such as Parkinson’s Disease. Here, the authors reveal a binding site of anle138b to lipid-induced α-synuclein fibrils.

Leif Antonschmidt
Dirk Matthes
Loren B. Andreas
ResearchOpen Access14 Sept 2022
Nature Communications

Volume: 13, P: 1-10
The quantum nature of skyrmions and half-skyrmions in Cu₂OSeO₃

In chiral helimagnets, the Dzyaloshinskii–Moriya interaction is known to stabilize skyrmions, but the microscopic roots remain enigmatic. Here, Janson et al. apply a multi-scale approach to Cu₂OSeO₃and show that its skyrmions can be traced back to magnetic tetrahedra of a quantum nature.

Oleg Janson
Ioannis Rousochatzakis
Helge Rosner
Research04 Nov 2014
Nature Communications

Volume: 5, P: 1-11
The isotopic signature of the “arthropod rain” in a temperate forest

Oksana L. Rozanova
Sergey M. Tsurikov
Eugenia E. Semenina
ResearchOpen Access10 Jan 2022
Scientific Reports

Volume: 12, P: 1-8
Effects of pharmacological modulators of α-synuclein and tau aggregation and internalization

Antonio Dominguez-Meijide
Eftychia Vasili
Tiago F. Outeiro
ResearchOpen Access30 Jul 2020
Scientific Reports

Volume: 10, P: 1-18
The small molecule inhibitor anle145c thermodynamically traps human islet amyloid peptide in the form of non-cytotoxic oligomers

Manikam S. Saravanan
Sergey Ryazanov
J. Antoinette Killian
ResearchOpen Access13 Dec 2019
Scientific Reports

Volume: 9, P: 1-12
Iron-mediated aggregation and toxicity in a novel neuronal cell culture model with inducible alpha-synuclein expression

Martin Bartels
Daniel Weckbecker
Armin Giese
ResearchOpen Access24 Jun 2019
Scientific Reports

Volume: 9, P: 1-13

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Cholesterol-mediated allosteric regulation of the mitochondrial translocator protein structure

Anle138b binds predominantly to the central cavity in lipidic Aβ₄₀ fibrils and modulates fibril formation

The clinical drug candidate anle138b binds in a cavity of lipidic α-synuclein fibrils

The quantum nature of skyrmions and half-skyrmions in Cu₂OSeO₃

The isotopic signature of the “arthropod rain” in a temperate forest

Effects of pharmacological modulators of α-synuclein and tau aggregation and internalization

The small molecule inhibitor anle145c thermodynamically traps human islet amyloid peptide in the form of non-cytotoxic oligomers

Iron-mediated aggregation and toxicity in a novel neuronal cell culture model with inducible alpha-synuclein expression

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