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Showing 1–4 of 4 results
Advanced filters: Author: Andrei Loas Clear advanced filters

  • Mirror-image phage display has the potential for high-throughput generation of biologically stable macrocyclic D-peptide binders but is hindered by the optimization required for D-protein chemical synthesis. Here, the authors report a general mirror-image phage display pipeline based on automated flow peptide synthesis and use it to prepare and characterize 12 L/D-protein pairs.

    • Alex J. Callahan
    • Satish Gandhesiri
    • Bradley L. Pentelute
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-13

  • PMOs (phosphorodiamidate morpholino oligomers) have huge potential for antisense therapy but complex and slow synthesis limits application. Here, the authors report the development of automated flow synthesis methods which reduce nucleobase coupling times from hours to minutes removing human errors and allow for high-throughput production.

    • Chengxi Li
    • Alex J. Callahan
    • Bradley L. Pentelute
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-8

  • Machine learning has now been shown to enable the de novo design of abiotic nuclear-targeting miniproteins. To achieve this, high-throughput experimentation was combined with a directed evolution-inspired deep-learning approach in which the molecular structures of natural and unnatural residues are represented as topological fingerprints. The designed miniproteins, called Mach proteins, are non-toxic and can efficiently deliver antisense cargo in mice.

    • Carly K. Schissel
    • Somesh Mohapatra
    • Bradley L. Pentelute
    Research
    Nature Chemistry
    Volume: 13, P: 992-1000

  • Angiotensin converting enzyme 2 (ACE2) has been identified as a cardiovascular disease biomarker and the primary receptor utilized by SARS-CoV-2, but developing serum-stable, selective and high-affinity binders for this target is challenging. Here, the authors use affinity selection-mass spectrometry to identify multiple high affinity ACE2-binding peptides from canonical and noncanonical peptidomimetic libraries containing 200 million members.

    • Genwei Zhang
    • Joseph S. Brown
    • Bradley L. Pentelute
    ResearchOpen Access
    Communications Chemistry
    Volume: 5, P: 1-10