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Heart failure-induced cognitive dysfunction is mediated by intracellular Ca²⁺ leak through ryanodine receptor type 2

Dridi et al. identified a mechanism for cognitive dysfunction after heart failure in which hyper-adrenergic signaling and transforming growth factor-beta activation induced Ca²⁺ leak by RyR2 channels in hippocampal neurons.

Haikel Dridi
Yang Liu
Andrew R. Marks
ResearchOpen Access10 Jul 2023
Nature Neuroscience

Volume: 26, P: 1365-1378

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Heart failure-induced cognitive dysfunction is mediated by intracellular Ca2+ leak through ryanodine receptor type 2

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Heart failure-induced cognitive dysfunction is mediated by intracellular Ca²⁺ leak through ryanodine receptor type 2