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Hippo pathway regulation by phosphatidylinositol transfer protein and phosphoinositides

The marine compound microcolin B stimulates the Hippo pathway and selectively kills YAP-dependent cancer cells by inhibiting phosphatidylinositol transfer protein and depleting plasma membrane phosphatidylinositol-4-phosphate.

Fu-Long Li
Vivian Fu
Kun-Liang Guan
Research04 Jul 2022
Nature Chemical Biology

Volume: 18, P: 1076-1086

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