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Showing 1–3 of 3 results
Advanced filters: Author: Andres Ernesto Zucchetti Clear advanced filters

  • HLA-independent T cell receptors, in which the heavy and light chains of a chimeric antigen receptor are incorporated into the endogenous T cell receptor locus, are more effective than CD28-based chimeric antigen receptors at targeting tumors with low antigen expression.

    • Jorge Mansilla-Soto
    • Justin Eyquem
    • Michel Sadelain
    Research
    Nature Medicine
    Volume: 28, P: 345-352

  • The immune synapse at the interface between T cells and antigen-presenting cells manifests intense vesicular trafficking, but how the vesicles are sorted is still unclear. Here the authors show that, in activated T cells, the Golgin GMAP210 specifically conveys LAT+ vesicles to immune synapse allowing proper T cell activation.

    • Andres Ernesto Zucchetti
    • Laurence Bataille
    • Claire Hivroz
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-17

  • Morrison et al. find that in T-cells, the palmitoyl acetyltransferase DHHC18 palmitoylates the v-SNARE VAMP7 at Cys183 and show that a mutant that cannot be palmitoylated fails to localise to Golgi and traffic to the immune synapse after T-cell receptor activation. This study highlights the importance of palmitoylation in T-cell signalling.

    • Eliot Morrison
    • Tatjana Wegner
    • Christian Freund
    ResearchOpen Access
    Communications Biology
    Volume: 3, P: 1-9