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Showing 1–3 of 3 results
Advanced filters: Author: Andres Ramirez-Martinez Clear advanced filters

  • The nuclear envelope tethers chromatin to the nuclear periphery to control genome architecture. Here, the authors show that Net39 preserves the integrity and gene expression of muscle nuclei in mice, and it may contribute to the pathogenesis of Emery–Dreifuss muscular dystrophy.

    • Andres Ramirez-Martinez
    • Yichi Zhang
    • Eric N. Olson
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-12

  • During embryogenesis, the cytoplasmic protein Myomarker (MYMK) mediates muscle fibre formation by fusion of myoblasts. Here, the authors identify autosomal recessive mutations in MYMK that cause Carey-Fineman-Ziter syndrome in humans, and model the disease variants in zebrafish.

    • Silvio Alessandro Di Gioia
    • Samantha Connors
    • Elizabeth C. Engle
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-16

  • The application of genome-wide CRISPR–Cas9 screening coupled with a fluorescent reporter to interrogate the microRNA pathway reveals that continual transient phosphorylation of Argonaute 2 is required to maintain the global efficiency of microRNA-mediated repression.

    • Ryan J. Golden
    • Beibei Chen
    • Joshua T. Mendell
    Research
    Nature
    Volume: 542, P: 197-202