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The RIPK4–IRF6 signalling axis safeguards epidermal differentiation and barrier function

Signalling between the transcription factor IRF6 and the kinase RIPK4, in particular the phosphorylation of IRF6 by RIPK4, regulates epidermal differentiation and lipid metabolism, thereby maintaining the function of the epidermal barrier.

Nina Oberbeck
Victoria C. Pham
Vishva M. Dixit
Research02 Oct 2019
Nature

Volume: 574, P: 249-253

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The RIPK4–IRF6 signalling axis safeguards epidermal differentiation and barrier function

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