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Showing 1–3 of 3 results
Advanced filters: Author: Andrew D. Pannifer Clear advanced filters

  • The European Lead Factory combines assets and experience from major pharma with innovation and agility of academia and SMEs in a collaborative platform to expand access to high-throughput screening. With many successes heading towards the clinic, the organization is broadening its approach to screening and partnering.

    • Philip S. Jones
    • Sylviane Boucharens
    • Jon S. B. de Vlieger
    Comments & Opinion
    Nature Reviews Drug Discovery
    Volume: 21, P: 245-246

  • The efficacy of carbapenem antibiotics can be compromised by metallo-β-lactamases, but a high-throughput screen followed by optimization has now enabled the discovery of indole-2-carboxylates (InCs) as potent broad-spectrum metallo-β-lactamase inhibitors. The results highlight the potential of InC–carbapenem combinations for clinical use as well as mechanism-guided approaches to combatting globally disseminated antibiotic resistant mechanisms.

    • Jürgen Brem
    • Tharindi Panduwawala
    • Christopher J. Schofield
    Research
    Nature Chemistry
    Volume: 14, P: 15-24