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Showing 1–2 of 2 results
Advanced filters: Author: Andrew Derrico Clear advanced filters

  • Mast cells within the tumor microenvironment have controversial roles. Here, the authors show, using genetic mouse models, that in gastric cancer, mast cells at the periphery of the tumors are activated via cancer cell produced-IL33 and promote tumorigenesis by recruiting macrophages within the tumors.

    • Moritz F. Eissmann
    • Christine Dijkstra
    • Matthias Ernst
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-16

  • Sanz and colleagues examine B cell subsets in a cohort of patients with COVID-19. Severely ill patients have higher frequencies of activated extrafollicular T-bet+ B cells that form antibody-secreting cells, the majority of which express germline sequences and are reminiscent of antibody responses observed in patients with systemic lupus erythematosus during flares.

    • Matthew C. Woodruff
    • Richard P. Ramonell
    • Ignacio Sanz
    Research
    Nature Immunology
    Volume: 21, P: 1506-1516