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Showing 1–9 of 9 results
Advanced filters: Author: Andrew J. Gellman Clear advanced filters

  • α-Helix-mediated protein–protein interactions (PPIs) play a key role in the development of numerous infection and disease states. Modulating such interactions offers considerable therapeutic potential, however, identifying suitable inhibitors has proved challenging. This Review highlights recent and generic approaches for designing inhibitors of helix-mediated PPIs.

    • Valeria Azzarito
    • Kérya Long
    • Andrew J. Wilson
    Reviews
    Nature Chemistry
    Volume: 5, P: 161-173

  • Equilibrium adsorption of non-racemic mixtures of enantiomers onto an achiral surface is shown to lead to enantioenrichment by formation of homochiral clusters. Such auto-amplification must influence enantioselective processes such as heterogeneous catalysis, adsorption-based separations, and perhaps the processes that lead to the homochirality of life on Earth.

    • Yongju Yun
    • Andrew J. Gellman
    Research
    Nature Chemistry
    Volume: 7, P: 520-525

  • The role of catalysts is greater than simply increasing the rate of a reaction. Modifying nanoparticles enhances two significant catalyst attributes: selectivity and thermal stability.

    • Andrew J. Gellman
    • Nisha Shukla
    News & Views
    Nature Materials
    Volume: 8, P: 87-88

  • Here, the authors introduce a biosensing platform with multi-length-scale electrode architecture consisting of 3D printed silver micropillars decorated with graphene flakes. They demonstrate that this breaks a barrier to the biomolecule limit-of-detection, enabling detection down to femtomolar level.

    • Md. Azahar Ali
    • Chunshan Hu
    • Rahul Panat
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-16

  • Enantioselective C–C bond-forming reactions are underdeveloped in the biocatalysis toolbox. Now, engineering an efficient and promiscuous decarboxylative aldolase enzyme provides a solution to facilitate the convenient synthesis of non-standard γ-hydroxy amino acids from simple building blocks.

    • Jonathan M. Ellis
    • Meghan E. Campbell
    • Andrew R. Buller
    Research
    Nature Catalysis
    Volume: 5, P: 136-143

  • Chiral surfaces are fundamental materials for the preparation of enantiomerically pure pharmaceuticals. This Perspective discusses the recent advances in the fabrication of chiral surfaces and the progress towards scalable, high-surface-area, enantiomerically pure surfaces.

    • Nisha Shukla
    • Andrew J. Gellman
    Reviews
    Nature Materials
    Volume: 19, P: 939-945

  • An integrated analysis of over 100 single-cell and single-nucleus transcriptomics studies illustrates severe acute respiratory syndrome coronavirus 2 viral entry gene coexpression patterns across different human tissues, and shows association of age, smoking status and sex with viral entry gene expression in respiratory cell populations.

    • Christoph Muus
    • Malte D. Luecken
    • Xiaohui Zhang
    Research
    Nature Medicine
    Volume: 27, P: 546-559