When artificial polypeptides are conjugated to a variety of hydrophobic molecules such as chemotherapeutics, the resulting molecules spontaneously self-assemble into nanoparticles. Delivering the chemotherapeutics to a murine cancer model, the nanoparticles have a fourfold higher maximum tolerated dose than the free drug, and induce nearly complete tumour regression after a single dose.
- J. Andrew MacKay
- Mingnan Chen
- Ashutosh Chilkoti
