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Showing 1–6 of 6 results
Advanced filters: Author: Andrew K. Beppu Clear advanced filters

  • A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

    • Mari E. K. Niemi
    • Juha Karjalainen
    • Chloe Donohue
    ResearchOpen Access
    Nature
    Volume: 600, P: 472-477

  • After respiratory viral infection and in fibrotic lung disease, repair and remodeling processes particularly affect airway basal cell (BC) and alveolar epithelial cell populations. Here, using single cell transcriptomics and lineage tracing, the authors characterize this process and define roles for innate immune activation in the regulation of BC fate and alveolar remodeling.

    • Andrew K. Beppu
    • Juanjuan Zhao
    • Barry R. Stripp
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-16

  • This study documents recurrent sex chromosome turnovers in kiwifruit lineages and shows that sexual dimorphism is caused by a pleiotropic effect of a single sex-determining gene, transforming our understanding of the evolution of sex chromosomes and sexual dimorphisms.

    • Takashi Akagi
    • Erika Varkonyi-Gasic
    • Ikuo Kataoka
    Research
    Nature Plants
    Volume: 9, P: 393-402

  • A sex determination gene, FrBy, is identified in the dioecious kiwifruit and demonstrated to maintain male functions across angiosperm species. FrBy and the known female suppressor gene, SyGI, support the evolution of dioecy via the ‘two-mutations’ model.

    • Takashi Akagi
    • Sarah M. Pilkington
    • Ryutaro Tao
    Research
    Nature Plants
    Volume: 5, P: 801-809