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Showing 1–5 of 5 results
Advanced filters: Author: Andrew L. Markhard Clear advanced filters

  • Leveraging pythons as an extreme model of feeding and fasting behaviour, this study uncovers para-tyramine-O-sulphate as a conserved postprandial metabolite that links nutrient intake to energy balance by activating hypothalamic neurons and suppressing food intake in pythons and mice.

    • Shuke Xiao
    • Mengjie Wang
    • Jonathan Z. Long
    ResearchOpen Access
    Nature Metabolism
    P: 1-16

  • The authors identify an increased hepatic NADH/NAD+ ratio as an underlying metabolic parameter that is shaped by human genetic variation and contributes causally to key metabolic traits and diseases.

    • Russell P. Goodman
    • Andrew L. Markhard
    • Vamsi K. Mootha
    Research
    Nature
    Volume: 583, P: 122-126

  • The structure of the core region of the mitochondrial calcium uniporter (MCU) is determined by NMR and electron microscopy, revealing that MCU is a homo-pentamer with a specific transmembrane helix forming a hydrophilic pore across the membrane, and representing one of the largest membrane protein structures characterized by NMR spectroscopy.

    • Kirill Oxenoid
    • Ying Dong
    • James J. Chou
    Research
    Nature
    Volume: 533, P: 269-273