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Showing 1–6 of 6 results
Advanced filters: Author: Andrew P. VanDemark Clear advanced filters

  • Homologous repair of DNA double strand breaks in Saccharomyces cerevisiaeis dependent on several conserved Rad51 paralogs. Here the authors provide biochemical evidence that Rad55-Rad57 synergistically interacts with the Shu complex to promote Rad51 filament formation and homology directed repair.

    • William A. Gaines
    • Stephen K. Godin
    • Kara A. Bernstein
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-7

  • The homologous recombination machinery needs to be recruited at replication intermediates for accurate functioning. Here, the authors reveal that a Rad51 paralog-containing complex, called the Shu complex, recognizes and enables tolerance of predominantly lagging strand abasic sites.

    • Joel C. Rosenbaum
    • Braulio Bonilla
    • Kara A. Bernstein
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-11

  • Two new crystal structures suggest that the eukaryotic proteasome is a gated protease and that opening of the gate may be a regulated event.

    • Cecile M. Pickart
    • Andrew P. VanDemark
    News & Views
    Nature Structural Biology
    Volume: 7, P: 999-1001

  • Covalent attachment of ubiquitin-like proteins to other proteins drives numerous important physiological processes. The recent structure of an ubiquitin-like E1 enzyme provides insight into the curious assembly line–like mechanism that initiates all ubiquitin-related protein processing pathways.

    • Andrew P. VanDemark
    • Christopher P. Hill
    News & Views
    Nature Structural & Molecular Biology
    Volume: 10, P: 244-246

  • Ubiquitin-like proteins, including NEDD8, regulate a wide range of cellular processes and are mobilized by parallel biochemical pathways. A recent crystal structure explains how the NEDD8-specific E1 enzyme specifically recruits its cognate E2 enzyme by binding to a flexible N-terminal extension.

    • Andrew P VanDemark
    • Christopher P Hill
    News & Views
    Nature Structural & Molecular Biology
    Volume: 11, P: 908-909