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Showing 1–2 of 2 results
Advanced filters: Author: Andrew Rashoff Clear advanced filters

  • PFA tumours express high levels of EZHIP (also known as CXORF67). Here the authors find that EZHIP directly interacts with the active site of EZH2 and is a competitive inhibitor of PRC2 and that EZHIP gives rise to H3K27me3 genomic profile similar to the K27M oncohistone.

    • Siddhant U. Jain
    • Truman J. Do
    • Peter W. Lewis
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-14

  • Mediator is a multiprotein complex required to activate gene transcription by RNAPII. Here, the authors report that MED12 and MED13 are conditional positive regulators that facilitate the expression of genes depleted in active chromatin marks and the induction of gene expression in response to environmental stimuli in Arabidopsis.

    • Qikun Liu
    • Sylvain Bischof
    • Steven E. Jacobsen
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-13