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Showing 1–7 of 7 results
Advanced filters: Author: Andrew Sharabi Clear advanced filters

  • Tumor draining lymph nodes are essential for immunotherapy efficacy in head and neck squamous cell carcinoma (HNSCC). Here, the authors show that sequential tumor-directed radiotherapy and PD-1 inhibition and migratory CCR7+ dendritic cells are required for complete and durable tumor responses in HNSCC.

    • Robert Saddawi-Konefka
    • Riyam Al Msari
    • Joseph A. Califano
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-19

  • Components of the hedgehog signaling pathways play key roles during embryonic development and in several human diseases.

    • Andrew P. McMahon
    • Pao-Tien Chuang
    News & Views
    Nature Medicine
    Volume: 2, P: 1308-1310

  • A molecular tumor board (MTB) is often used as a platform that integrates clinical and molecular parameters for clinical decision making. Here, the authors review the outcome of 715 cancer patients presented at their institution’s MTB, and demonstrate that patients who received a MTB-recommended regimen received therapy that was better matched to their alterations and achieved better clinical outcomes.

    • Shumei Kato
    • Ki Hwan Kim
    • Razelle Kurzrock
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-9

  • Tobacco use is one of the major risk factors for Head and neck squamous cell carcinoma (HNSCC). Here, the authors report an immune-competent syngeneic mouse model that mimics human tobacco-related HNSCC, and develops tumors in the tongue, and report a high response rate to anti-CTLA-4 therapy.

    • Zhiyong Wang
    • Victoria H. Wu
    • J. Silvio Gutkind
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-13

  • Monomethyl auristatin (MMAE), also known for its radiosensitizer properties, is a common antibody drug conjugate used for cancer therapy. Here the authors show that, in combination with radiotherapy, tumor-directed antibodies or peptides conjugated to MMAE promote anti-tumor immune responses, improving response to checkpoint inhibitors in preclinical cancer models.

    • Dina V. Hingorani
    • Michael M. Allevato
    • Sunil J. Advani
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-16

  • Response rates to immune checkpoint inhibitors (ICI) in patients with head and neck squamous cell carcinoma (HNSCC) remain low. Here the authors show that ablative treatment of tumor-draining regional lymphatics, a standard of care approach in patients, impairs the tumor response to ICI in preclinical HNSCC models.

    • Robert Saddawi-Konefka
    • Aoife O’Farrell
    • J. Silvio Gutkind
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-19