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Showing 1–3 of 3 results
Advanced filters: Author: Andrew Sugarman Clear advanced filters

  • In a phase 1 trial, patients with pancreatic ductal adenocarcinoma who were treated with surgery and bespoke neoantigen mRNA vaccines combined with anti-PD-L1 and chemotherapy exhibited marked long-lived persistence of neoantigen-specific CD8+ T cell clones, which correlated with prolonged recurrence-free survival at a 3.2-year follow-up.

    • Zachary Sethna
    • Pablo Guasp
    • Vinod P. Balachandran
    ResearchOpen Access
    Nature
    Volume: 639, P: 1042-1051

  • Human enterovirus 71 (EV71) contains an internal ribosome entry site (IRES) that promotes translation of viral RNA. Here the authors show that an antiviral small molecule DMA-135 binds to the EV71 IRES RNA, inducing conformational change and stabilizing a ternary complex to repress translation.

    • Jesse Davila-Calderon
    • Neeraj N. Patwardhan
    • Blanton S. Tolbert
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-13

  • A phase I clinical trial of an adjuvant personalized mRNA neoantigen vaccine, autogene cevumeran, in patients with pancreatic ductal carcinoma demonstrates that the vaccine can induce T cell activity that may correlate with delayed recurrence of disease.

    • Luis A. Rojas
    • Zachary Sethna
    • Vinod P. Balachandran
    ResearchOpen Access
    Nature
    Volume: 618, P: 144-150