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Showing 1–2 of 2 results
Advanced filters: Author: Andrew T. Tebbenkamp Clear advanced filters

  • The implications of early telencephalic development in cortical disorders remain elusive. Here, the authors define risk gene dynamics and perturbation effects in neural stem cells, revealing vulnerability phases during early human corticogenesis.

    • Xoel Mato-Blanco
    • Suel-Kee Kim
    • Nicola Micali
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-23

  • Autism genes converge in midfetal cortical co-expression networks, and chromatin regulators such as CHD8 are increasingly associated with autism spectrum disorder (ASD). Here the authors map CHD8 targets in developing brain, and find that CHD8 directly regulates other ASD risk genes during human neurodevelopment.

    • Justin Cotney
    • Rebecca A. Muhle
    • James P. Noonan
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-11