The activation of Janus kinase 2 (JAK2), a non-receptor tyrosine kinase that regulates several cellular processes by inducing cytoplasmic signalling cascades, is a frequent event in haematological malignancies. Here, human JAK2 is shown to be present in the nucleus of haematopoietic cells, where it directly phosphorylates Tyr 41 on histone H3, thus preventing the binding of heterochromatin protein Iα.
- Mark A. Dawson
- Andrew J. Bannister
- Tony Kouzarides
