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Showing 1–4 of 4 results
Advanced filters: Author: Andrey Buyan Clear advanced filters

  • The authors present a statistical and computational framework to identify allele-specific variants, i.e., single nucleotide variants exhibiting allele-specificity (allelic imbalance) in any type of omics assay. Application of this framework to thousands of datasets yields an atlas of chromatin altering variants in diverse cell types.

    • Andrey Buyan
    • Georgy Meshcheryakov
    • Ivan V. Kulakovskiy
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-19

  • RNA binding proteins (RBPs) regulate various RNA processes, yet their interactions remain poorly understood. Here, authors generate a comprehensive map of RBP interactions using multimodal data, uncovering context-specific functions and revealing complex post-transcriptional regulatory networks.

    • Matvei Khoroshkin
    • Andrey Buyan
    • Hani Goodarzi
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-21

  • Deviatiiarov, Gams et al. provide an atlas of the actively transcribed regulatory elements (promoters and enhancers) in the human heart by performing cap analysis of gene expression (CAGE) on 21 healthy donor hearts and ten failing hearts from ischemic and non-ischemic cardiomyopathy. The data show how the alternative use of regulatory elements modulates the differential gene expression across different heart chambers, disease states and disease types.

    • Ruslan M. Deviatiiarov
    • Anna Gams
    • Igor R. Efimov
    Research
    Nature Cardiovascular Research
    Volume: 2, P: 58-75