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Deep mutational learning for the selection of therapeutic antibodies resistant to the evolution of Omicron variants of SARS-CoV-2

Therapeutic antibodies with enhanced resistance to the evolution of SARS-CoV-2 can be identified via deep mutational learning by screening a combinatorial library of receptor-binding domains for antibody binding and escape.

Lester Frei
Beichen Gao
Sai T. Reddy
ResearchOpen Access05 Mar 2025
Nature Biomedical Engineering

Volume: 9, P: 552-565
The active site residues Gln55 and Arg73 play a key role in DNA damage bypass by S. cerevisiae Pol η

Elizaveta O. Boldinova
Artem Ignatov
Alena V. Makarova
ResearchOpen Access09 Jul 2018
Scientific Reports

Volume: 8, P: 1-11

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Deep mutational learning for the selection of therapeutic antibodies resistant to the evolution of Omicron variants of SARS-CoV-2

The active site residues Gln55 and Arg73 play a key role in DNA damage bypass by S. cerevisiae Pol η

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