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Showing 1–8 of 8 results
Advanced filters: Author: Andrey Tvardovskiy Clear advanced filters

  • In this Tools of the Trade article, Andrey Tvardovskiy and Saulius Lukauskas introduce the web resource MARCS, which offers a set of visualization tools to explore chromatin regulatory circuits from either a protein- or modification-centred perspective.

    • Andrey Tvardovskiy
    • Saulius Lukauskas
    Research Highlights
    Nature Reviews Genetics
    Volume: 25, P: 673-674

  • A multidimensional proteomics analysis of the interactions between around 2,000 nuclear proteins and over 80 modified dinucleosomes representing promoter, enhancer and heterochromatin states provides insights into how chromatin states are decoded by chromatin readers.

    • Saulius Lukauskas
    • Andrey Tvardovskiy
    • Till Bartke
    ResearchOpen Access
    Nature
    Volume: 627, P: 671-679

  • PRC2 preferentially binds G tracts within nascent pre-mRNAs, causing transfer of PRC2 from chromatin to RNA upon gene activation, thus providing a mechanism to selectively remove PRC2 from specific genes.

    • Manuel Beltran
    • Manuel Tavares
    • Richard G. Jenner
    Research
    Nature Structural & Molecular Biology
    Volume: 26, P: 899-909

  • Although mechanisms wherein pre-existing H3K27 methylation directs recruitment of PRC2 to support its own maintenance have been proposed, H3K27 methylation patterns in mESCs are not dependent on self-autonomous epigenetic inheritance.

    • Jonas W. Højfeldt
    • Anne Laugesen
    • Kristian Helin
    Research
    Nature Structural & Molecular Biology
    Volume: 25, P: 225-232

  • Although mutant H3K27M histones inhibit PRC2 in diffuse intrinsic pontine gliomas, these tumors exhibit significant amounts of PRC2 activity. The repression of several genes, including INK4A, by residual EZH2 activity is required for tumor growth, and EZH2 inhibitors therefore represent potential therapies for these patients.

    • Faizaan Mohammad
    • Simon Weissmann
    • Kristian Helin
    Research
    Nature Medicine
    Volume: 23, P: 483-492