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Showing 1–7 of 7 results
Advanced filters: Author: Andrey V. Kajava Clear advanced filters

  • The structural rules governing the curving folds of solenoid proteins, as distilled down to the level of the underlying sequence repeats, provide designers with the tools to reliably fashion new variants with tunable geometries. Bespoke leucine-rich repeat (LRR) scaffolds, as recognition proteins, can now be tailored to better fit their targets.

    • J Fernando Bazan
    • Andrey V Kajava
    News & Views
    Nature Structural & Molecular Biology
    Volume: 22, P: 103-105

  • p53 isoform Δ133p53β is reported to promote intrinsic oncogenic functions. Here the authors show Δ133p53β is sequestered as aggregates in an inactive form, while association with interacting partners including p63 isoforms and the CCT chaperone complex promotes Δ133p53β activity, resulting in enhanced cancer cell migration and invasion.

    • Nikola Arsic
    • Tania Slatter
    • Pierre Roux
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-18

  • Here, the authors evaluate the performance of AlphaFold2 and its predicted structures on common structural biological applications, including missense variants, function and ligand binding site prediction, modeling of interactions and modeling of experimental structural data.

    • Mehmet Akdel
    • Douglas E. V. Pires
    • Pedro Beltrao
    ResearchOpen Access
    Nature Structural & Molecular Biology
    Volume: 29, P: 1056-1067

  • The retromer is a complex of Vacuolar protein sorting proteins that mediate retrieval of lysosomal hydrolases from endosomes to the trans golgi network. The human retromer complex can be separated into two smaller complexes, a membrane targeting sorting nexin dimer and a heterotrimeric cargo recognition complex. New and previously solved structures, bioinformatics, interaction studies, molecular modelling and electron microscopy of the entire complex are combined to develop a structural model of the complex.

    • Aitor Hierro
    • Adriana L. Rojas
    • James H. Hurley
    Research
    Nature
    Volume: 449, P: 1063-1067

  • Results are presented from the first Critical Assessment of protein Intrinsic Disorder prediction (CAID) experiment, a community-based blind test to determine the state of the art in predicting intrinsically disordered regions in proteins.

    • Marco Necci
    • Damiano Piovesan
    • Silvio C. E. Tosatto
    ResearchOpen Access
    Nature Methods
    Volume: 18, P: 472-481