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Impact of dhps mutations on sulfadoxine-pyrimethamine protective efficacy and implications for malaria chemoprevention

Malaria chemoprevention is used for young children, but resistance mutations raise concerns on efficacy. In this analysis of trials across Africa, the authors show that prevention treatment protects >42 days against susceptible parasites but <12 days against highly resistant strains highlighting the importance of genomic surveillance for chemoprevention strategies.

Andria Mousa
Gina Cuomo-Dannenburg
Cally Roper
ResearchOpen Access08 May 2025
Nature Communications

Volume: 16, P: 1-13
Estimating the burden of severe malarial anaemia and access to hospital care in East Africa

Severe malarial anaemia is a clinical manifestation of severe malaria, with the burden highly concentrated in children. In this work, authors statistically model household survey and in-hospital data to estimate the proportion of severe malarial anaemia cases that access hospital care.

Peter Winskill
Aggrey Dhabangi
Lucy C. Okell
ResearchOpen Access14 Sept 2023
Nature Communications

Volume: 14, P: 1-7
Projected health impact of post-discharge malaria chemoprevention among children with severe malarial anaemia in Africa

Trial data have shown that post-discharge malaria chemoprevention (PDMC) reduces the risk of readmission and death in children previously hospitalised with severe malarial anaemia. Here, the authors use mathematical modelling to estimate the potential epidemiological impacts of PDMC in malaria-endemic countries in Africa.

Lucy C. Okell
Titus K. Kwambai
Amani Thomas Mori
ResearchOpen Access25 Jan 2023
Nature Communications

Volume: 14, P: 1-10
Children’s role in the COVID-19 pandemic: a systematic review of early surveillance data on susceptibility, severity, and transmissibility

Katy A. M. Gaythorpe
Sangeeta Bhatia
Neil M. Ferguson
ResearchOpen Access06 Jul 2021
Scientific Reports

Volume: 11, P: 1-14
Publisher Correction: Children’s role in the COVID-19 pandemic: a systematic review of early surveillance data on susceptibility, severity, and transmissibility

Katy A. M. Gaythorpe
Sangeeta Bhatia
Neil M. Ferguson
Amendments and CorrectionsOpen Access16 Sept 2021
Scientific Reports

Volume: 11, P: 1-2

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Impact of dhps mutations on sulfadoxine-pyrimethamine protective efficacy and implications for malaria chemoprevention

Estimating the burden of severe malarial anaemia and access to hospital care in East Africa

Projected health impact of post-discharge malaria chemoprevention among children with severe malarial anaemia in Africa

Children’s role in the COVID-19 pandemic: a systematic review of early surveillance data on susceptibility, severity, and transmissibility

Publisher Correction: Children’s role in the COVID-19 pandemic: a systematic review of early surveillance data on susceptibility, severity, and transmissibility

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