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Showing 1–20 of 20 results
Advanced filters: Author: Andrzej Dziembowski Clear advanced filters

  • CCR4-NOT is a protein complex involved in a variety of important genetic processes. Here, the authors report the mid-resolution structure of this complex, and model the positions and contacts between the subunits, providing structural support for the previously reported functions of the complex.

    • Marta Ukleja
    • Jorge Cuellar
    • Jose M. Valpuesta
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-11

  • Circular RNAs offer advantages for mRNA therapies but are challenging to produce. Here, the authors develop a chemical method to generate circular RNAs with internal cap structures, enabling cap-dependent translation, chemical modification, and enhanced stability.

    • Malgorzata Wasinska-Kalwa
    • Adam Mamot
    • Jacek Jemielity
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-15

  • Upon intramuscular administration, COVID-19 mRNA vaccines are primarily taken up by macrophages, in which the cellular machinery extends their poly(A) tails, thereby increasing mRNA stability and translation, providing an explanation for the efficacy of these vaccines.

    • Paweł S. Krawczyk
    • Michał Mazur
    • Seweryn Mroczek
    ResearchOpen Access
    Nature
    Volume: 641, P: 984-992

  • The exosome is a multisubunit exonuclease complex that degrades many types of RNAs, in many different contexts, in a 3′ to 5′ manner. The catalytic component of the exosome is the Dis3 subunit. Dis3 contains a PIN domain, which is sometimes associated with nuclease activity. This work shows that the Dis3 PIN domain also possesses endonuclease activity (that is, it can cleave RNA internally, rather than from an end). Mutations in either this domain or in the exonuclease domain exhibit a growth phenotype, suggesting that both activities are physiologically important.

    • Alice Lebreton
    • Rafal Tomecki
    • Bertrand Séraphin
    Research
    Nature
    Volume: 456, P: 993-996

  • RNA polyadenosine tails are important for the export, translation and stability of mRNAs and play a role in non-coding RNA biogenesis. Here the authors measure yeast poly(A) tail lengths by direct RNA sequencing, revealing its dynamics in yeast exonuclease, deadenylase and poly(A) polymerase mutants.

    • Agnieszka Tudek
    • Paweł S. Krawczyk
    • Andrzej Dziembowski
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-14

  • A previously unidentified class of variable stars has been found in OGLE survey data, characterized by periodic brightness variations on ~30-min timescales, amplitudes of ~0.3 mag and temperatures of ~30,000 K. They are potentially evolved low-mass stars.

    • Paweł Pietrukowicz
    • Wojciech A. Dziembowski
    • Krzysztof Ulaczyk
    Research
    Nature Astronomy
    Volume: 1, P: 1-7

  • TUTase mediated uridylation of mRNA promotes degradation. Here, Scheer, de Almeida et al. show that Arabidopsis TUTase URT1 interacts directly with the translation inhibitor and decay factor DECAPPING5 and suppresses siRNA biogenesis by preventing accumulation of deadenylated mRNAs

    • Hélène Scheer
    • Caroline de Almeida
    • Dominique Gagliardi
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-17

  • G-rich RNAs encoded in mitochondrial DNA are prone to form four-stranded structures called G-quadruplexes (G4s). Here the authors show using in vitro and in vivo approaches that GRSF1 promotes melting of G4 RNA structures in mtRNAs, thus leading to their decay by the hSuv3–PNPase complex.

    • Zbigniew Pietras
    • Magdalena A. Wojcik
    • Roman J. Szczesny
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-15

  • Regulating polyadenylation is important for mRNA stability, which can in turn affect B cell maturation and humoral immune responses. Here the authors use Nanopore poly(A) sequencing to explore the importance of the cytoplasmic poly(A) polymerase TENT5C, particularly in the production of immunoglobulins.

    • Aleksandra Bilska
    • Monika Kusio-Kobiałka
    • Seweryn Mroczek
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-17

  • Ligase D is a conserved DNA repair protein complex that repairs double-strand breaks in stationary phase prokaryotes. Here the authors show that orthologous Ligase C has a role in base excision repair during stationary phase.

    • Przemysław Płociński
    • Nigel C. Brissett
    • Aidan J. Doherty
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-12

  • FAM46C is one of the most frequently mutated genes in multiple myeloma (MM), but its molecular function remains unknown. Here the authors show that FAM46C is a poly(A) polymerase and that loss of function of FAM46C drives multiple myeloma through the destabilisation of ER response transcripts.

    • Seweryn Mroczek
    • Justyna Chlebowska
    • Andrzej Dziembowski
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-17

  • The mitochondrial RNA degradosome (mtEXO) plays an essential role in the regulation of mitochondrial gene expression and is composed of the 3′-to-5′ exoribonuclease Dss1 and the helicase Suv3. Here the authors present the RNA bound mtEXO crystal structure and give insights into its mechanism.

    • Michal Razew
    • Zbigniew Warkocki
    • Marcin Nowotny
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-12

  • Mitochondrial dysfunction and cellular protein homeostasis failure are hallmarks of many diseases and age-associated pathologies; this study shows that the mitochondrial import defect of nuclear-encoded proteins triggers a cellular pathway, termed unfolded protein response activated by mistargeting of proteins (UPRam), that acts to minimize the stress caused by non-imported mitochondrial precursor proteins in order to sustain cellular protein homeostasis and organismal fitness.

    • Lidia Wrobel
    • Ulrike Topf
    • Agnieszka Chacinska
    Research
    Nature
    Volume: 524, P: 485-488