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Showing 1–16 of 16 results
Advanced filters: Author: Andy Dobson Clear advanced filters

  • An analysis of 24,202 critical cases of COVID-19 identifies potentially druggable targets in inflammatory signalling (JAK1), monocyte–macrophage activation and endothelial permeability (PDE4A), immunometabolism (SLC2A5 and AK5), and host factors required for viral entry and replication (TMPRSS2 and RAB2A).

    • Erola Pairo-Castineira
    • Konrad Rawlik
    • J. Kenneth Baillie
    ResearchOpen Access
    Nature
    Volume: 617, P: 764-768

  • Whole-genome sequencing, transcriptome-wide association and fine-mapping analyses in over 7,000 individuals with critical COVID-19 are used to identify 16 independent variants that are associated with severe illness in COVID-19.

    • Athanasios Kousathanas
    • Erola Pairo-Castineira
    • J. Kenneth Baillie
    ResearchOpen Access
    Nature
    Volume: 607, P: 97-103

  • Investigations of an Icelandic volcanic eruption confirm that sulfate aerosols caused a discernible yet transient brightening effect, as predicted, but their effect on the liquid water path was unexpectedly negligible.

    • Florent F. Malavelle
    • Jim M. Haywood
    • Thorvaldur Thordarson
    Research
    Nature
    Volume: 546, P: 485-491

  • Sahelian drought is investigated by analysing de-trended observations between 1900 and 2010, which show that substantial Northern Hemisphere volcanic eruptions preceded three of the four driest summers. Modelling both episodic volcanic eruptions and geoengineering by continuous deliberate stratospheric injection shows that large asymmetric aerosol loadings in the Northern Hemisphere are a precursor of Sahelian drought, whereas if the aerosol loadings are concentrated in the Southern Hemisphere greening of the Sahel is induced.

    • Jim M. Haywood
    • Andy Jones
    • David Stephenson
    Research
    Nature Climate Change
    Volume: 3, P: 660-665

  • Solar geoengineering has been proposed as a means of mitigating the warming effects of climate change, yet the consequences of such action remain uncertain. Here, using a general circulation model, the authors evaluate the effect of stratospheric aerosol injection on tropical cyclone activity.

    • Anthony C. Jones
    • James M. Haywood
    • Andy Jones
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-10

  • Here, the seismic anisotropy of the Earth's lowermost mantle between North and Central America has been measured, using shallow and deep earthquakes to increase the azimuthal coverage. The findings show that the previously assumed vertical transverse isotropy — where wave speed should show no azimuthal variation — is not possible, and that more complicated mechanisms must be involved.

    • Andy Nowacki
    • James Wookey
    • J-Michael Kendall
    Research
    Nature
    Volume: 467, P: 1091-1094

  • A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

    • Mari E. K. Niemi
    • Juha Karjalainen
    • Chloe Donohue
    ResearchOpen Access
    Nature
    Volume: 600, P: 472-477

  • Transcriptomic analysis of BCR-ABL1 lymphoblastic leukemia identifies three subgroups, each associated with a maturation arrest at a specific stage of B-cell progenitor differentiation and distinct genetic and clinical features.

    • Jaeseung C. Kim
    • Michelle Chan-Seng-Yue
    • Faiyaz Notta
    ResearchOpen Access
    Nature Genetics
    Volume: 55, P: 1186-1197

    • Andy Dobson
    Books & Arts
    Nature Ecology & Evolution
    Volume: 7, P: 965

  • The harlequin frogs of tropical America are at the sharp end of climate change. About two-thirds of their species have died out, and altered patterns of infection because of changes in temperature seem to be the cause.

    • Andrew R. Blaustein
    • Andy Dobson
    News & Views
    Nature
    Volume: 439, P: 143-144

  • A genome-wide association study of critically ill patients with COVID-19 identifies genetic signals that relate to important host antiviral defence mechanisms and mediators of inflammatory organ damage that may be targeted by repurposing drug treatments.

    • Erola Pairo-Castineira
    • Sara Clohisey
    • J. Kenneth Baillie
    Research
    Nature
    Volume: 591, P: 92-98

  • Adopting early dry season fires has been proposed as a means of generating sufficient carbon revenues to pay for conservation in Africa. However, the climatic impact thereof is deeply questionable and may have unforeseen detrimental effects.

    • Tony Knowles
    • Nicola Stevens
    • Sally Archibald
    Reviews
    Nature Sustainability
    Volume: 8, P: 226-233