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Showing 1–2 of 2 results
Advanced filters: Author: Angela Brentrup Clear advanced filters

  • Embryonal tumour with multilayered rosettes (ETMR) is a rare and aggressive paediatric brain tumour. Here, the authors analyse intratumour heterogeneity and the tumour microenvironment in ETMR using single-cell and spatial transcriptomics, in vitro cultures, and a 3D forebrain organoid model, finding important aspects – such as the communication with pericytes – for ETMR development and response to therapy.

    • Flavia W. de Faria
    • Nicole C. Riedel
    • Kornelius Kerl
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-19

  • The MAPK pathway is a key driver of pediatric low-grade gliomas (pLGG); however, response to MAPK inhibitors (MAPKi) in pLGG patients is not consistent. Here, the authors develop MAPKi sensitivity scores (MSS) to predict response to MAPKi and apply them to bulk and single-cell sequencing datasets from pLGG patients and preclinical models.

    • Romain Sigaud
    • Thomas K. Albert
    • Till Milde
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-21