Nature Search

Targeting of NAT10 enhances healthspan in a mouse model of human accelerated aging syndrome

Hutchinson-Gilford Progeria Syndrome is characterized by premature aging with cardiovascular disease being the main cause of death. Here the authors show that inhibition of the NAT10 enzyme enhances cardiac function and fitness, and reduces age-related phenotypes in a mouse model of premature aging.

Gabriel Balmus
Delphine Larrieu
Stephen P. Jackson
ResearchOpen Access27 Apr 2018
Nature Communications

Volume: 9, P: 1-14
A comparison of chromosome instability in cell suspensions of diploid, tetraploid and hexaploid wheats

Mark Winfield
Michael R Davey
Angela Karp
Research01 Feb 1993
Heredity

Volume: 70, P: 187-194
Publisher Correction: Targeting of NAT10 enhances healthspan in a mouse model of human accelerated aging syndrome

Gabriel Balmus
Delphine Larrieu
Stephen P. Jackson
Amendments and CorrectionsOpen Access18 Mar 2026
Nature Communications

Volume: 17, P: 1
The effects of nucleotype and genotype upon pollen grain development in Hyacinth and Scilla

Angela Karp
H Rees
A W Jewell
Research01 Apr 1982
Heredity

Volume: 48, P: 251-261
Prevalence of sexual dimorphism in mammalian phenotypic traits

Systemic dissection of sexually dimorphic phenotypes in mice is lacking. Here, Karp and the International Mouse Phenotype Consortium show that approximately 10% of qualitative traits and 56% of quantitative traits in mice as measured in laboratory setting are sexually dimorphic.

Natasha A. Karp
Jeremy Mason
Jacqueline K. White
ResearchOpen Access26 Jun 2017
Nature Communications

Volume: 8, P: 1-12
Imipramine and Sexual Dysfunction during the Long-term Treatment of Recurrent Depression

Jordan F. Karp
Ellen Frank
David J. Kupfer
Research01 Aug 1994
Neuropsychopharmacology

Volume: 11, P: 21-27
Biotechnology, Biodiversity, and Conservation

Angela Karp
David S. Ingram
Comments & Opinion01 May 1995
Bio/Technology

Volume: 13, P: 522
Mapping the human genetic architecture of COVID-19

A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

Mari E. K. Niemi
Juha Karjalainen
Chloe Donohue
ResearchOpen Access08 Jul 2021
Nature

Volume: 600, P: 472-477
Whole-genome sequencing reveals host factors underlying critical COVID-19

Whole-genome sequencing, transcriptome-wide association and fine-mapping analyses in over 7,000 individuals with critical COVID-19 are used to identify 16 independent variants that are associated with severe illness in COVID-19.

Athanasios Kousathanas
Erola Pairo-Castineira
J. Kenneth Baillie
ResearchOpen Access07 Mar 2022
Nature

Volume: 607, P: 97-103
The Sex Inclusive Research Framework to address sex bias in preclinical research proposals

In preclinical research, there is a persistent sex bias where research is conducted with a single sex. Here, the authors present a Sex Inclusive Research Framework that provides a traffic light classification of research proposals to facilitate robust assessment and promote equitable sex inclusion

Natasha A. Karp
Manuel Berdoy
Lucy Whitfield
ReviewsOpen Access22 Apr 2025
Nature Communications

Volume: 16, P: 1-6
Foveolar thickness as potential standardized structural outcome measurement in studies of Bietti crystalline dystrophy

Laura A. Jenny
Pei-Kang Liu
Stephen H. Tsang
ResearchOpen Access29 Aug 2022
Scientific Reports

Volume: 12, P: 1-10
Human leukocyte antigen alleles associate with COVID-19 vaccine immunogenicity and risk of breakthrough infection

Variation in antibody levels elicited by the COVID-19 vaccine ChAdOx1 nCov-19 is linked to specific major histocompatibility complex class II alleles, providing insight into the breadth of immune response among vaccinated individuals.

Alexander J. Mentzer
Daniel O’Connor
Julian C. Knight
ResearchOpen Access13 Oct 2022
Nature Medicine

Volume: 29, P: 147-157
Genetic determinants of micronucleus formation in vivo

Genetic screening identifies a rich catalogue of regulators of micronucleus formation.

D. J. Adams
B. Barlas
G. Balmus
ResearchOpen Access14 Feb 2024
Nature

Volume: 627, P: 130-136
Growing innovations for the bioeconomy

Agriculture is often viewed as a source of problems needing innovative solutions. But agriculture can actually be a source of innovations for the bioeconomy, if researchers embrace the cultural changes needed.

Angela Karp
Michael H. Beale
Achim Dobermann
Comments & Opinion01 Dec 2015
Nature Plants

Volume: 1, P: 1-3
Molecular technologies for biodiversity evaluation: Opportunities and challenges

New technologies for detecting variation in DNA complement traditional methods in biodiversity.

Angela Karp
Keith J. Edwards
Godfrey M. Hewitt
Special Features01 Jul 1997
Nature Biotechnology

Volume: 15, P: 625-628
A survey on the practices and the management of hemorrhagic cystitis in patients who undergo allogeneic hematopoietic stem cell transplantation, on behalf of the Infectious Diseases Working Party of EBMT

Simone Cesaro
Inge Verheggen
Dina Averbuch
Research26 Aug 2025
Bone Marrow Transplantation

Volume: 60, P: 1480-1486
Key knowledge gaps to achieve global sustainability goals

Based on assessments of the Intergovernmental Science-Policy Platform for Biodiversity and Ecosystem Services, key research priorities are identified and contrasted with the SDGs and the Millennium Ecosystem Assessment.

Matías E. Mastrángelo
Natalia Pérez-Harguindeguy
Kim Zoeller
Research28 Oct 2019
Nature Sustainability

Volume: 2, P: 1115-1121
Common variation near CDKN1A, POLD3 and SHROOM2 influences colorectal cancer risk

Richard Houlston and colleagues report a genome-wide association study for colorectal cancer. They report three loci newly associated with colorectal cancer, bringing the total number of common susceptibility loci to 20.

Malcolm G Dunlop
Sara E Dobbins
Richard S Houlston
Research27 May 2012
Nature Genetics

Volume: 44, P: 770-776
Gene and pathway level analyses of germline DNA-repair gene variants and prostate cancer susceptibility using the iCOGS-genotyping array

Edward J Saunders
Tokhir Dadaev
Zsofia Kote-Jarai
ResearchOpen Access10 Mar 2016
British Journal of Cancer

Volume: 114, P: 945-952
Discovery of four recessive developmental disorders using probabilistic genotype and phenotype matching among 4,125 families

Matthew Hurles, David FitzPatrick and colleagues report the discovery of four novel Mendelian disorders based on their analysis of exome sequence data from 4,125 families with diverse rare developmental disorders. They present their analytical pipeline as a general strategy for the discovery of genetic causes of autosomal recessive disorders.

Nadia Akawi
Jeremy McRae
Matthew E Hurles
Research05 Oct 2015
Nature Genetics

Volume: 47, P: 1363-1369

Search

Targeting of NAT10 enhances healthspan in a mouse model of human accelerated aging syndrome

A comparison of chromosome instability in cell suspensions of diploid, tetraploid and hexaploid wheats

Publisher Correction: Targeting of NAT10 enhances healthspan in a mouse model of human accelerated aging syndrome

The effects of nucleotype and genotype upon pollen grain development in Hyacinth and Scilla

Prevalence of sexual dimorphism in mammalian phenotypic traits

Imipramine and Sexual Dysfunction during the Long-term Treatment of Recurrent Depression

Biotechnology, Biodiversity, and Conservation

Mapping the human genetic architecture of COVID-19

Whole-genome sequencing reveals host factors underlying critical COVID-19

The Sex Inclusive Research Framework to address sex bias in preclinical research proposals

Foveolar thickness as potential standardized structural outcome measurement in studies of Bietti crystalline dystrophy

Human leukocyte antigen alleles associate with COVID-19 vaccine immunogenicity and risk of breakthrough infection

Genetic determinants of micronucleus formation in vivo

Growing innovations for the bioeconomy

Molecular technologies for biodiversity evaluation: Opportunities and challenges

A survey on the practices and the management of hemorrhagic cystitis in patients who undergo allogeneic hematopoietic stem cell transplantation, on behalf of the Infectious Diseases Working Party of EBMT

Key knowledge gaps to achieve global sustainability goals

Common variation near CDKN1A, POLD3 and SHROOM2 influences colorectal cancer risk

Gene and pathway level analyses of germline DNA-repair gene variants and prostate cancer susceptibility using the iCOGS-genotyping array

Discovery of four recessive developmental disorders using probabilistic genotype and phenotype matching among 4,125 families

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