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Showing 1–5 of 5 results
Advanced filters: Author: Angela Malaspina Clear advanced filters
  • The US National Institute of Allergy and Infectious Diseases (NIAID) convened a virtual workshop in July 2022 to address the research landscape and identify gaps and opportunities in the understanding of durable vaccine protection.

    • Amy C. Palin
    • Galit Alter
    • M. Patricia D’Souza
    News & Views
    Nature Immunology
    Volume: 23, P: 1665-1668
  • Until recently, few potent and broadly neutralizing HIV-specific antibodies had been identified, but recent findings have inspired optimism that an effective HIV vaccine can finally be developed. Here we review these studies, which used state-of-the-art high-throughput techniques to collectively describe hundreds of new potent and broad HIV-neutralizing antibodies isolated from HIV-infected individuals.

    • Susan Moir
    • Angela Malaspina
    • Anthony S Fauci
    Comments & Opinion
    Nature Structural & Molecular Biology
    Volume: 18, P: 1317-1321
  • Advances in HIV vaccine development focus on eliciting broadly neutralizing antibodies (bNAbs) through next-generation immunogens. Human trials are testing these candidates for their ability to initiate B cell maturation. This workshop report reviews emerging data and methods for analyzing B cell repertoires, highlighting strategies to streamline these labor-intensive processes. The goal is to enable timely, cost-effective design of sequential immunization regimens that induce potent, protective bNAbs against HIV.

    • Milton Maciel Jr.
    • Lindsey R. Baden
    • M. Patricia D’Souza
    News & ViewsOpen Access
    npj Vaccines
    Volume: 10, P: 1-7